Well, it's not the best place to save money....but I try to not buy sale items. Also, Whole Foods "395" brand are great products, and usually great prices for organic items. (canned goods, etc).

Also look for stacks of coupon booklets at the register. They are usually piled up where the baggers stand, so get one of those before you start shopping. If you can match coupons with sales, there are very very decent deals!